Renal injury following long-term exposure to carbon disulfide: analysis of a case series
| Autor: | De-Hua Zeng, Cheng Wang, Zhi-Yong Zheng, Li-Juan Qu, Min Li, Yong-Qin Yan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty Pathology Tubular atrophy 030232 urology & nephrology Carbon disulfide lcsh:RC870-923 Nephropathy Blood Urea Nitrogen 03 medical and health sciences 0302 clinical medicine Internal medicine Occupational Exposure medicine Humans Serum amyloid A Mesangial Nodular mesangial hyperplasia/sclerosis Hematuria Inhalation Exposure medicine.diagnostic_test business.industry Glomerulosclerosis Focal Segmental Glomerulonephritis Idiopathic Hyperplasia medicine.disease lcsh:Diseases of the genitourinary system. Urology Glomerular Mesangium Proteinuria 030220 oncology & carcinogenesis Creatinine Immunohistochemistry Kidney Failure Chronic Renal biopsy business Glomeruli Research Article |
| Zdroj: | BMC Nephrology BMC Nephrology, Vol 20, Iss 1, Pp 1-7 (2019) |
| ISSN: | 1471-2369 |
| Popis: | Background To investigate the clinicopathological characteristics of renal damage caused by long-term exposure to carbon disulfide (CS2) in nine patients. Methods All the patients underwent ultrasound-guided renal biopsy. All specimens were examined by light microscopy and immunohistochemistry (IHC). Samples form one patient were further analyzed using transmission electron microscopy. Results Similar pathological changes were observed in all patients, but the degrees of lesions were different. All cases had moderate to severe nodular mesangial hyperplasia; among these, type “Kimme1stie1-Wi1son” (K-W nodule for short) was observed in four cases, type “K - W nodule” refer to nodular hyperplasia of mesangial membrane like letter K or W. four cases had proliferative extracapillary glomerulonephritis (GN), while there were no concomitant changes in one patient. Besides, six cases had diffuse basement membrane thickening, focal segmental sclerosis or bulbar sclerosis; two cases had diffuse glomerular sclerosis, and one case had focal segmental capillary hyperplasia. Moreover, all patients had renal tubular atrophy/interstitial fibrosis with less to moderate chronic inflammatory cell infiltration, as well as renal arteriosclerosis. IHC showed that the depositions of IgA, IgM, C3d, C4d, C1q and Fib were not specific; while IgG, type III collagen, Fibronectin, Amyloid A, Igκ, Igλ, HBsAg and HBcAg were all negative. Conclusion Diffuse nodular mesangial hyperplasia/sclerosing glomerular nephropathy is characterized by nodular mesangial hyperplasia with type “K-W nodules” formation, which we speculate is a special pathological manifestation of renal damage caused by carbon disulfide (CS2). |
| Databáze: | OpenAIRE |
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