Cells and mediators of inflammation as effectors of epithelial repair in the inflamed intestine
| Autor: | Bianca Crifo, Wallace K. MacNaughton |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Inflammation
0303 health sciences Hepatology Colon Physiology Gastroenterology Epithelial Cells Inflammatory Bowel Diseases 3. Good health Intestines 03 medical and health sciences 0302 clinical medicine Physiology (medical) Cytokines Homeostasis Humans 030211 gastroenterology & hepatology Inflammation Mediators Intestinal Mucosa 030304 developmental biology |
| Zdroj: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 322:G169-G182 |
| ISSN: | 1522-1547 0193-1857 |
| Popis: | Mucosal and histological healing have become the gold standards for assessing the efficacy of therapy in patients living with inflammatory bowel diseases (IBD). Despite these being the accepted goals in therapy, the mechanisms that underlie the healing of the mucosa after an inflammatory insult are not well understood, and many patients fail to meet this therapeutic endpoint. Here we review the emerging evidence that mediators (e.g., prostaglandins, cytokines, proteases, reactive oxygen, and nitrogen species) and innate immune cells (e.g., neutrophils and monocytes/macrophages), that are involved in the initiation of the inflammatory response, are also key players in the mechanisms underlying mucosal healing to resolve chronic inflammation in the colon. The dual function mediators comprise an inflammation/repair program that returns damaged tissue to homeostasis. Understanding details of the dual mechanisms of these mediators and cells may provide the basis for the development of drugs that can help to stimulate epithelial repair in patients affected by IBD. |
| Databáze: | OpenAIRE |
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