Desmoplasia and Chemoresistance in Pancreatic Cancer
| Autor: | Ralf Jesenofsky, Stephan L. Haas, Cornelius Weidenauer, Wolfgang Hagmann, J.-Matthias Löhr, Ralf Faissner, Rainer Heuchel, Patrick Michl, Marvin Schober |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
cancer stem cells Cancer Research medicine.medical_specialty Pathology Stromal cell pancreatic cancer Review Drug resistance de novo resistance lcsh:RC254-282 Cancer stem cell Pancreatic cancer Internal medicine CAM-DR medicine SFM-DR drug resistance business.industry desmoplasia Mortality rate Cancer medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens matrix Desmoplasia future therapies Cancer cell medicine.symptom business |
| Zdroj: | Cancers, Vol 6, Iss 4, Pp 2137-2154 (2014) Cancers |
| ISSN: | 2072-6694 |
| Popis: | Pancreatic ductal adenocarcinoma (PDAC) occurs mainly in people older than 50 years of age. Although great strides have been taken in treating PDAC over the past decades its incidence nearly equals its mortality rate and it was quoted as the 4th leading cause of cancer deaths in the U.S. in 2012. This review aims to focus on research models and scientific developments that help to explain the extraordinary resistance of PDAC towards current therapeutic regimens. Furthermore, it highlights the main features of drug resistance including mechanisms promoted by cancer cells or cancer stem cells (CSCs), as well as stromal cells, and the acellular components surrounding the tumor cells—known as peritumoral desmoplasia—that affects intra-tumoral drug delivery. Finally, therapeutic concepts and avenues for future research are suggested, based on the topics discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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