Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram
| Autor: | Regina Pietruszko, Robert C. Vallari |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Cytoplasm
Reducing agent Aldehyde dehydrogenase Catalysis chemistry.chemical_compound Disulfiram medicine Humans Sulfhydryl Compounds chemistry.chemical_classification Multidisciplinary Human liver biology ADH1B Glutathione Aldehyde Dehydrogenase Aldehyde Oxidoreductases Isoenzymes Enzyme chemistry Biochemistry Liver biology.protein Oxidation-Reduction medicine.drug |
| Zdroj: | Science (New York, N.Y.). 216(4546) |
| ISSN: | 0036-8075 |
| Popis: | Disulfiram labeled with carbon-14 reacts specifically with human liver aldehyde dehydrogenase E1 with loss of catalytic activity and no incorporation of label. Carbon-14-labeled diethyldithiocarbamate is formed and the number of enzyme sulfhydryl groups decreases from 34 to 30 during this process. Activity is recovered by-mercaptoethanol but not by glutathione, the physiological reducing agent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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