Total Synthesis of Tricyclic Azaspirane Derivatives of Tyrosine: FR901483 and TAN1251C
| Autor: | Norbert A. Braun, Marco A. Ciufolini, C. Bavoux, Malika Ousmer, Monique Perrin |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
chemistry.chemical_classification
Aza Compounds Oxidative cyclization Chemistry Total synthesis General Chemistry Oxazoline Biochemistry Catalysis chemistry.chemical_compound Organophosphorus Compounds Colloid and Surface Chemistry Azaspirane Organic chemistry Spiro Compounds Tyrosine Immunosuppressive Agents Tricyclic |
| Zdroj: | Journal of the American Chemical Society. 123:7534-7538 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja016030z |
| Popis: | A solution to the long-standing problem presented by the oxidative cyclization of a phenolic 3-arylpropionamide to a spirolactam has been developed in this laboratory via oxazoline chemistry. This research was motivated by our interest in some novel tricyclic azaspirane natural products formally derived from tyrosine, such as FR901483 and TAN1251C. In this paper, we disclose full details of the total synthesis of these substances. |
| Databáze: | OpenAIRE |
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