Influence of Heat Shock Protein (HSP-70) Enhancing Compound From Red Alga (Porphyridium cruentum) for Augmenting Egg Production in Copepod Culture – A New In Silico Report
| Autor: | R. Vijayaraj, Kareem Altaff |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Balıkçılık Reproductive Biology biology Deniz ve Tatlı Su Biyolojisi Tryptophan Fisheries Tryptophan synthase Phenylalanine biology.organism_classification Bioactive compound Üreme Biyolojisi Amino acid chemistry.chemical_compound chemistry Biochemistry Porphyridium cruentum Biosynthesis Denizcilik biology.protein General Earth and Planetary Sciences Marine Science Tyrosine Marine and Freshwater Biology Copepod Microalgae Arachidonic acid Porphyridium cruentum HSP-70 |
| Zdroj: | Volume: 10, Issue: 2 186-192 Marine Science and Technology Bulletin |
| ISSN: | 2147-9666 |
| Popis: | The present study reports in silico investigation of bioactive compounds from marine microalgae capable of escalating copepod fecundity potential through enhanced heat shock protein (HSP-70) production. The structure of ligand (bioactive compounds from microalgae) and hsp-70 obtained from the databases of PubChem and Protein Data Bank (PDB), respectively. Molecular Docking was performed by GOLD software and ligand interaction pathways using web server MANORAA. Fourteen bioactive compounds showed good biding interaction with specific protein HSP-70 and seven of these compounds showed high hydrogen bond interaction with key amino acids (phenylalanine, tyrosine and tryptophan). The highest binding energy of 50.21 is recorded in the bioactive compound, arachidonic acid from the red alga Porphyridium cruentum TYR 167 involved in the biosynthesis pathway of phenylalanine, tyrosine and tryptophan also showed specific target site of tryptophan synthase (4.2.1.20). Results suggest with P. cruentum feed copepod culture could boost their fecundity leading to high density culture. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|