Grade 3 and 4 Toxicity Profiles During Therapy of Childhood Acute Lymphoblastic Leukemia
| Autor: | Joanna Zawitkowska, Andrzej Kołtan, Joanna Owoc-Lempach, Joanna Trelińska, Katarzyna Drabko, Grażyna Karolczyk, Aleksandra Kiermasz, Monika Lejman, Maciej Niedźwiecki, Katarzyna Derwich, Joanna Bulsa, Magdalena Ćwiklińska, Marcin Płonowski, Tomarz Ociepa, Agnieszka Mizia-Malarz, Michał Romiszewski, Agnieszka Zaucha-Prażmo, Jerzy Kowalczyk |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Multivariate analysis Adolescent Drug-Related Side Effects and Adverse Reactions Biopsy medicine.medical_treatment Lymphoblastic Leukemia Severity of Illness Index General Biochemistry Genetics and Molecular Biology Immunophenotyping 03 medical and health sciences 0302 clinical medicine Risk groups Internal medicine Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor medicine Overall survival Humans Genetic Testing Child Childhood Acute Lymphoblastic Leukemia Pharmacology Univariate analysis Chemotherapy business.industry Age Factors Infant Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis Child Preschool 030220 oncology & carcinogenesis Toxicity Female business Research Article |
| Zdroj: | In Vivo. 33:1333-1339 |
| ISSN: | 1791-7549 0258-851X |
| DOI: | 10.21873/invivo.11608 |
| Popis: | Background/aim The risk factors, clinical features and non-hematological toxicity profiles during chemotherapy in acute lymphoblastic leukemia (ALL) patients treated in pediatric hematology centres were analysed. Materials and methods A total of 902/1872 children were reported as having grade 3 or 4 toxicity. Results Among the analysed toxicities, infection and gastrointestinal and liver toxicities were the most common. The median follow-up was 6.8 years. Overall survival and event-free survival rates for the analysed group were lower than those reported for the group without grade ≥3 toxicity. In univariate analysis, we identified the number of toxic episodes, the risk group and remission status that had a significant impact on the outcome. Multivariate analysis demonstrated the risk group and the number of toxic episodes ≥3 to be statistically significant for the results. Conclusion The toxic profiles investigated in our report should be used in future efforts to decrease the burden of side effects during chemotherapy. |
| Databáze: | OpenAIRE |
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