Changes in Markers of Thrombin Generation and IL-6 during Unicondylar Knee and Total Knee Arthroplasty
| Autor: | Allina A. Nocon, Edwin P. Su, George Go, Nigel E. Sharrock, Lauren E. Mount, Thomas P. Sculco |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
Male Risk medicine.medical_specialty Knee Joint medicine.medical_treatment Antithrombin III Total knee arthroplasty Thrombin generation Article 03 medical and health sciences 0302 clinical medicine medicine Humans Orthopedics and Sports Medicine 030212 general & internal medicine Prospective Studies Unicondylar Knee Arthroplasty Unicompartmental knee arthroplasty Interleukin 6 Arthroplasty Replacement Knee Intraoperative Complications Aged 030222 orthopedics Tourniquet biology business.industry Interleukin-6 Thrombin Middle Aged Osteoarthritis Knee Surgery Relative risk Anesthesia biology.protein Female Prothrombin business Tranexamic acid Biomarkers medicine.drug Peptide Hydrolases |
| Popis: | BACKGROUND: Total knee arthroplasty (TKA) is associated with a risk of thromboembolism requiring routine thromboprophylaxis, but there is debate about the risk with unicondylar knee arthroplasty (UKA) as it is believed to be a less invasive, more minor procedure with regard to surgical trauma. Because of this gap in knowledge, we sought to investigate the relative risk of thromboembolism with UKA compared to TKA and one-staged bilateral TKA (BTKA) by measuring the increase in circulating biochemical markers of coagulation at various time-points during the procedures. At the same time, we wanted to assess the relative degree of surgical trauma during the procedures by measuring IL-6, a marker of metabolic injury. METHODS: We prospectively studied a total of 75 patients: 25 patients undergoing UKA, unilateral TKA and BTKA respectively. All patients had neuraxial anesthesia, surgery performed with tourniquet and received no heparin or tranexamic acid (TXA). Radial artery blood samples were taken at four periods during surgery and assayed for circulating markers of thrombin generation: prothrombin fragment 1+2 (F1+2) and thrombin-antithrombin complexes (TAT); and a marker of metabolic injury, interleukin-6 (IL6), using ELISA assays. RESULTS: The circulating marker of thrombin generation, TAT, increased during all time-points (p |
| Databáze: | OpenAIRE |
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