Effects of gonadotropin-releasing hormone agonist/recombinant follicle-stimulating hormone versus gonadotropin-releasing hormone antagonist/recombinant follicle-stimulating hormone on follicular fluid levels of adhesion molecules during in vitro fertilization
| Autor: | Felice Fornaro, Nicola Colacurci, Simona Sorrentino, Argyrò Tassou, Daniela Mele, Domenico De Lucia, Barbara Badolati, Luigi Cobellis |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty medicine.drug_class medicine.medical_treatment Fertilization in Vitro Biology Gonadotropin-releasing hormone antagonist Gonadotropin-Releasing Hormone Follicle-stimulating hormone Ovulation Induction Internal medicine Gonadotropin-releasing hormone agonist Follicular phase medicine Humans In vitro fertilisation Ovary Obstetrics and Gynecology Intercellular adhesion molecule Oocyte Follicular fluid Follicular Fluid Drug Combinations medicine.anatomical_structure Endocrinology Treatment Outcome Reproductive Medicine Female Follicle Stimulating Hormone Human Cell Adhesion Molecules hormones hormone substitutes and hormone antagonists |
| Zdroj: | Fertility and sterility. 87(1) |
| ISSN: | 1556-5653 |
| Popis: | Objective To compare the effects of GnRH–agonist/recombinant rFSH versus GnRH-antagonist/recombinant FSH stimulation on follicular fluid levels of soluble intercellular adhesion molecule (sICAM)-1 and vascular cell adhesion molecule-1 (sVCAM-1) during in vitro fertilization (IVF). Design Prospective, randomized study. Setting University hospital. Patient(s) Seventy-three women underwent IVF. Intervention(s) GnRH-agonist/rFSH or GnRH-antagonist/rFSH administration and collection of follicular fluid from 3 small (11–14 mm in diameter) and 3 large (18–21 mm in diameter) follicles on the day of oocyte retrieval. Main Outcome Measure(s) Follicular fluid levels of sICAM-1 and sVCAM-1 and intrafollicular estradiol and progesterone were also measured. Result(s) Women who underwent GnRH-agonist/rFSH showed higher concentrations of sICAM-1 in both small and large follicles were compared with patients who received GnRH-antagonist/rFSH treatment; follicular fluid levels of sVCAM-1 were similar between the 2 stimulation protocols. Content of sICAM-1 in small and large follicles positively correlated with the number of follicles of ≥15 mm and the number of oocytes that were retrieved in both study groups. Concentrations of follicular fluid sVCAM-1 and progesterone were higher in large than in small follicles and were correlated positively to each other in both follicular classes. Conclusion(s) In IVF, GnRH-agonist/rFSH is associated with higher follicular fluid levels of sICAM-1 compared with GnRH-antagonist/rFSH regimen. Intrafollicular sICAM-1 content may predict ovarian response, and sVCAM-1 appears as an indicator of the degree of follicular luteinization. |
| Databáze: | OpenAIRE |
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