Stored Platelets Release Nucleotides as Inhibitors of Platelet Function
| Autor: | C. W. N. Gouwerok, Dirk de Korte, M. N. Boomgaard, H. A. Veldman, Dirk Roos, R. Fijnheer, Christa H. E. Homburg, J. M. Van Den Eertwegh |
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| Přispěvatelé: | Medical oncology |
| Rok vydání: | 1992 |
| Předmět: | |
| Zdroj: | Thrombosis and Haemostasis, 68(5), 595-599. Schattauer GmbH Fijnheer, R, Boomgaard, M N, Van den Eertwegh, A J M, Homburg, C H E, Gouwerok, C W N, Veldman, H A, Roos, D & De Korte, D 1992, ' Stored platelets release nucleotides as inhibitors of platelet function ', Thrombosis and Haemostasis, vol. 68, no. 5, pp. 595-599 . https://doi.org/10.1055/s-0038-1646323 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1055/s-0038-1646323 |
| Popis: | SummaryIt is well known that the function of platelets decreases progressively during storage of platelet concentrates at room temperature. To investigate this phenomenon in more detail, we have resuspended platelets that had been stored for 24 h or 72 h in fresh plasma, and we have measured the aggregation response and the ATP secretion. Conversely, the effect of plasma in which platelet concentrates (PC) had been stored for 24 h or 72 h, was tested on fresh platelets. Both the aggregation response to collagen and ADP and the collagen-induced ATP secretion of stored platelets partially recovered after incubation with fresh plasma (p These data show that stored platelets release nucleotides that inhibit platelet function in a reversible manner. This phenomenon may contribute to the decrease of platelet function during storage and the recovery of platelet function after transfusion. |
| Databáze: | OpenAIRE |
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