3D high resolution clonogenic survival measurement of xrs-5 cells in low-dose region of carbon ion plans
| Autor: | Dea Kartini, Olga Sokol, Chutima Talabnin, Chinorat Kobdaj, Marco Durante, Michael Krämer, Martina Fuss |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International journal of radiation biology 1, 1-11 (2022). doi:10.1080/09553002.2022.2110318 International Journal of Radiation Biology |
| ISSN: | 1362-3095 |
| Popis: | In this study, we performed biological verification measurements of cell survival of aWe established the protocol for a 3D culture setup where xrs-5 cells were grown inside a layered matrigel structure in 384-well plates. Their radiosensitivity to conventional andDose response curves following X-ray andWe conclude that the V-bottom 384-well plates in combination with the radiation-sensitive xrs-5 cell line constitute a suitable radiobiological verification tool which can be used especially for low doses. Furthermore, the measured survival of xrs-5 cells show a good agreement with the expected survival in the low-dose out-of-field regions, both laterally and downstream of the target. |
| Databáze: | OpenAIRE |
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