Prognostic significance of tumor volume as determined on 3D ultrasound scan in uterine cervix cancer treated by radiotherapy
| Autor: | Awadhesh Kumar Dixit, Shelly Srivastava, Surendra Kumar Saini, Deepti Dwivedi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_treatment Uterine Cervical Neoplasms lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Imaging Three-Dimensional Medicine Humans Radiology Nuclear Medicine and imaging 3D ultrasound External beam radiotherapy Prospective Studies Stage (cooking) Prospective cohort study cervix volume radiotherapy Aged Ultrasonography 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Ultrasound Hazard ratio Cancer cervix General Medicine Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prognosis Survival Analysis Log-rank test Radiation therapy Oncology 030220 oncology & carcinogenesis Female three-dimensional ultrasound business Nuclear medicine |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 13, Iss 2, Pp 324-328 (2017) |
| ISSN: | 1998-4138 |
| Popis: | Aims: The aim of this prospective study is to evaluate prognostic significance of tumor volume determined by three-dimensional (3D) ultrasound scan in uterine cervix cancer patients treated by radiotherapy. Patients and Methods: A total of 67 patients of Stage IB2-IIIB were studied and analyzed. Cervical tumor volume was determined by 3D ultrasound scan. Two groups were made on the basis of volume on ultrasound scan (Group 1 40 cc = 31). Both groups received external beam radiotherapy (EBRT) and intracavitary radiation therapy (ICRT). Cisplatin 40 mg/m 2 every week was given concurrently with external irradiation. Tumor volumes were taken by 3D USG every week during EBRT, after each fraction of ICRT, and after 8 weeks of completion of treatment. Primary end point was disease-free survival (DFS), and secondary endpoints were 5-year survival and toxicities. Results: After 2 months of completion of treatment, 1 out of 36 patients of Group A was having residual and 7 out of 31 of Group B were having residual diseases (P = 0.034). DFS and 5-year survival were significantly different in the groups (log rank test P = 0.0014, hazard ratio (HR) =2.3622 95% confidence interval (CI) 1.3090–4.2625 and P = 0.0421, HR = 1.9274 95% CI 0.9998–3.7156, respectively). Conclusions: Ultrasound is a cheap, simple, and useful in predicting the outcome of treatment and DFS based on the tumor volume. |
| Databáze: | OpenAIRE |
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