The use of stem cells in plastic and reconstructive surgery
| Autor: | Piotr Wójcicki, Maciej Koźlik |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Reconstructive surgery Cellular differentiation Medicine (miscellaneous) Adipose tissue Cosmetic Techniques Regenerative Medicine General Biochemistry Genetics and Molecular Biology Paracrine signalling Internal Medicine medicine Animals Humans Regeneration Pharmacology (medical) Cell Lineage Genetics (clinical) Cell Proliferation business.industry Regeneration (biology) Cell Differentiation Plastic Surgery Procedures Surgery Clinical trial Treatment Outcome Reviews and References (medical) Stem cell business Adult stem cell Stem Cell Transplantation |
| Zdroj: | Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 23(6) |
| ISSN: | 1899-5276 |
| Popis: | As part of their clinical practice, plastic surgeons perform procedures in the fields of skin and adipose tissue grafting, the reconstruction of compound tissue loss and congenital malformations, the treatment of acute and chronic wounds and burns, as well as cosmetic surgery. On account of the great expectations associated with their use in therapy, stem cells (SCs) are increasingly frequently employed in in vitro experiments, animal models and clinical trials. The most commonly utilized SCs for these purposes are adult stem cells (AS), which are present in small amounts in every tissue; among these are two types of cells: bone marrow mesenchymal stem cells (BM-MSCs) and adipose-derived stem cells (ADSCs). The aim of this review is to present current findings in experimental research on the use of stem cells in the field of plastic and reconstructive surgery. Many studies have described the progress of trials using ADSCs and BM-MSCs mainly in the treatment of compound tissue loss and chronic wounds. The use of their paracrine, proangiogenic and osteogenic functions is emphasized. However, because of the very high harvesting and culturing expenses and the limited availability of data on their safety for human use, SCs are not a first-choice therapy. Further developments in SC research and gradually decreasing costs mean that along with commercial-scale SC culturing, the use of SCs will become a viable alternative to traditional surgical procedures. |
| Databáze: | OpenAIRE |
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