Hemodynamic coherence in sepsis
| Autor: | Andrea Morelli, Maurizio Passariello |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
microvascular dysfunction microcirculation Hemodynamics Inflammation microvessels 030204 cardiovascular system & hematology hemodynamics Microcirculation sepsis fluid therapy Sepsis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine humans Intensive care medicine Total flow business.industry Septic shock Organ dysfunction microvascular resuscitation septic shock anesthesiology and pain medicine 030208 emergency & critical care medicine medicine.disease Pathophysiology Anesthesiology and Pain Medicine Cardiology medicine.symptom business |
| Zdroj: | Best Practice & Research Clinical Anaesthesiology. 30:453-463 |
| ISSN: | 1521-6896 |
| Popis: | Microvascular alterations are a hallmark of sepsis and play a crucial role in its pathophysiology. Such alterations are the result of overwhelming inflammation, which negatively affects all the components of the microcirculation. As the severity of microvascular alterations is associated with organ dysfunction and mortality, several strategies have been tested for improving microcirculation. Nevertheless, they are mainly based on the conventional manipulation of systemic hemodynamics to increase the total flow to the organs and tissues. Other therapeutic interventions are still being investigated. In this review, we discuss the pathophysiology of septic microcirculatory dysfunction and its implications for possible treatments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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