Pretreatment Serum Testosterone Level as a Predictive Factor of Pathological Stage in Localized Prostate Cancer Patients Treated with Radical Prostatectomy
| Autor: | Akira Komiya, Satoshi Fukasawa, Masahiko Inahara, Takashi Imamoto, Hiroyoshi Suzuki, Tomohiko Ichikawa, Masaki Shimbo, Taizo Shiraishi, Takeshi Ueda |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Biochemical recurrence medicine.medical_specialty Urology medicine.medical_treatment urologic and male genital diseases Prostate cancer Predictive Value of Tests Internal medicine medicine Humans Testosterone Clinical significance Aged Neoplasm Staging Prostatectomy business.industry Age Factors Prostatic Neoplasms Cancer Middle Aged Prognosis medicine.disease Extraprostatic Endocrinology Predictive value of tests Multivariate Analysis Neoplasm Recurrence Local business Biomarkers |
| Zdroj: | European Urology. 47:308-312 |
| ISSN: | 0302-2838 |
| DOI: | 10.1016/j.eururo.2004.11.003 |
| Popis: | Objective: Pretreatment serum level of testosterone (T) is a potential prognostic factor for prostate cancer. The present study was conducted to evaluate the clinical significance of pretreatment serum T level in patients with clinically localized prostate cancer. Materials and Methods: The subjects were 82 clinically localized prostate cancer patients treated with radical prostatectomy, whose pretreatment T levels were recorded. We investigated clinical and pathological factors such as pretreatment serum T level, age, pretreatment PSA or pathological Gleason score concerning the association with pathological stage and biochemical recurrence. Results: The mean pretreatment T level was significantly lower in patients with non-organ-confined prostate cancer (pT3–T4, N1; 3.44±1.19ng/ml) than in patients with organ-confined cancer (pT2; 4.33±1.42ng/ml) ( p =0.0078). Multivariate analysis demonstrated that pathological Gleason score, pretreatment serum T level and pretreatment PSA were significant predictors of extraprostatic disease. When the patients were divided into high and low T level groups according to the median value, pretreatment T levels were not significantly associated with PSA recurrence rates ( p =0.7973). Conclusions: A lower pretreatment T level appears to be predictive of extraprostatic disease in patients with localized prostate cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect