In VitroAntimicrobial and Antiproliferative Activity ofAmphipterygium adstringens

Autor: I. T. A. Peixoto, Ana Lúcia Tasca Gois Ruiz, María Julia Verde-Star, Hamlet Avilés-Arnaut, S. De la Torre-Zavala, Aida Rodriguez-Garcia
Rok vydání: 2015
Předmět:
Zdroj: Evidence-Based Complementary and Alternative Medicine, Vol 2015 (2015)
Evidence-based Complementary and Alternative Medicine : eCAM
ISSN: 1741-4288
1741-427X
DOI: 10.1155/2015/175497
Popis: Amphipterygium adstringensis a plant widely used in Mexican traditional medicine for its known anti-inflammatory and antiulcer properties. In this work, we evaluated thein vitroantimicrobial and antiproliferative activities of the methanolic extract ofA. adstringensagainst oral pathogens such asStreptococcus mutans,Porphyromonas gingivalis,Aggregatibacter actinomycetemcomitans,Candida albicans, andCandida dubliniensis, using microdilution (MIC) and agar diffusion methods (MBC), and the antiproliferative activity evaluating total growth inhibition (TGI) by staining the protein content with sulforhodamine B (SRB), using nine human cancer cell lines. Crude extract (CE) ofA. adstringensshowed some degree of activity against one or more of the strains with a MIC from 0.125 mg/mL to 63 mg/mL and MBC from 1.6 to 6.3 mg/mL and cytotoxic activity, particularly against NCI-ADR/RES, an ovarian cell line expressing multiple resistance drugs phenotype. The CE is a complex mixture of possible multitarget metabolites that could be responsible for both antimicrobial and antiproliferative activities, and further investigation is required to elucidate the identity of active compounds. Nevertheless the CE itself is useful in the development of new antimicrobial treatment based on natural products to prevent oral diseases and as alternative natural source for cancer treatment and prevention.
Databáze: OpenAIRE
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