Preclinical mouse model of optical coherence tomography for subcortical brain imaging without dissection
| Autor: | Kyoung Hyup Nam, Jae Meen Lee, Minkyu Kim, Seunghwan Song, Dong Hwan Kim, Heejeong Park, Jae Il Lee, Inho Han, Hongki Kim, Jeonghun Choi |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
genetic structures H&E stain General Physics and Astronomy Neuroimaging Dissection (medical) General Biochemistry Genetics and Molecular Biology Lesion Mice Optical coherence tomography medicine Animals General Materials Science Intraoperative imaging Intracerebral hemorrhage medicine.diagnostic_test business.industry Dissection General Engineering Brain General Chemistry medicine.disease eye diseases sense organs Neurosurgery medicine.symptom Nuclear medicine business Tomography Optical Coherence |
| Zdroj: | Journal of Biophotonics. 14 |
| ISSN: | 1864-0648 1864-063X |
| DOI: | 10.1002/jbio.202100143 |
| Popis: | The purpose of this study was to investigate the feasibility of using optical coherence tomography (OCT) to identify internal brain lesions, specifically intracerebral hemorrhage, without dissection. Mice with artificially injected brain hematomas were used to test the OCT system, and the recorded images were compared with microscopic images of the same mouse brains after hematoxylin and eosin staining. The intracranial structures surrounding the hematomas were clearly visualized by the OCT system without dissection. These images reflect the ability of OCT to determine the extent of a lesion in several planes. OCT is a useful technology, and these findings could be used as a starting point for future research in intraoperative imaging. |
| Databáze: | OpenAIRE |
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