The influence of skeletal muscle on appetite regulation
| Autor: | Giuseppe De Vito, Carel W. le Roux, John C Murphy, Andrew Grannell |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
exercise
Hunger muscle weight loss medicine.medical_specialty Endocrinology Diabetes and Metabolism Energy balance Appetite 030209 endocrinology & metabolism Weight Gain 03 medical and health sciences 0302 clinical medicine Weight loss Internal medicine Weight Loss medicine Homeostasis Humans Muscle Skeletal Exercise Chemistry Appetite Regulation Skeletal muscle medicine.anatomical_structure Endocrinology 030220 oncology & carcinogenesis medicine.symptom Energy Intake Energy Metabolism Appetite regulation |
| Zdroj: | Expert review of endocrinologymetabolism. 14(4) |
| ISSN: | 1744-8417 |
| Popis: | Fat-free mass, of which skeletal muscle is amajor component, correlates positively with energy intake at energy balance. This is due to the effects of metabolically active tissue on energy expenditure which in itself appears to signal to the brain adrive to eat to ensure cellular energy homeostasis. The mechanisms responsible for this drive to eat are unknown but are likely to be related to energy utilization. Here muscle imparts an indirect influence on hunger. The drive to eat is also enhanced after muscle loss secondary to intentional weight loss. The evidence suggests loss of both fat mass and skeletal muscle mass directly influences the trajectory and magnitude of weight regain highlighting their potential role in long-termappetite control. The mechanisms responsible for the potential direct drive to eat stemming from muscle loss are unknown.The literature pertaining to muscle and appetite at energy balance and after weight loss was examined. Aliterature search was conducted to identify studies related to appetite, muscle, exercise, and weight loss.Understanding the mechanisms which link energy expenditure and muscle loss to hunger has the potential to positively impact both the prevention and the treatment of obesity. |
| Databáze: | OpenAIRE |
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