Coupling of Geant4-DNA physics models into the GATE Monte Carlo platform: Evaluation of radiation-induced damage for clinical and preclinical radiation therapy beams
| Autor: | A. Dufaure, Yann Perrot, Q.T. Pham, Sang Bae Lee, Lydia Maigne, A. Anne, M. Bony, Gerard Montarou, E. Delage, Sebastien Incerti, M. Gautier, J. I. Shin, P. Micheau, D. Donnarieix |
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| Přispěvatelé: | Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Proton Therapy Center, National Cancer Center Korea, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Coupling
Physics Nuclear and High Energy Physics Proton Geant4-DNA medicine.medical_treatment Monte Carlo method Physics::Medical Physics GATE Nanotechnology computer.file_format Electron Protein Data Bank [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation Computational physics Radiation therapy medicine Physics::Accelerator Physics Nanodosimetry Instrumentation computer Monte Carlo Beam (structure) Energy (signal processing) |
| Zdroj: | Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2015, 353, pp.46-55. ⟨10.1016/j.nimb.2015.04.024⟩ Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Elsevier, 2015, 353, pp.46-55. ⟨10.1016/j.nimb.2015.04.024⟩ |
| ISSN: | 0168-583X |
| DOI: | 10.1016/j.nimb.2015.04.024⟩ |
| Popis: | International audience; The GATE Monte Carlo simulation platform based on the Geant4 toolkit is in constant improvement for dosimetric calculations. In this paper, we present the integration of Geant4-DNA processes into the GATE 7.0 platform in the objective to perform multi-scale simulations (from macroscopic to nanometer scale). We simulated three types of clinical and preclinical beams: a 6 MeV electron clinical beam, a X-ray irradiator beam and a clinical proton beam for which we validated depth dose distributions against measurements in water. Frequencies of energy depositions and DNA damage were evaluated using a specific algorithm in charge of allocating energy depositions to atoms constituting DNA molecules represented by their PDB (Protein Data Bank) description. |
| Databáze: | OpenAIRE |
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