Meta-Analysis Reveals Significant Sex Differences in Chronic Lymphocytic Leukemia Progression in the Eµ-TCL1 Transgenic Mouse Model
| Autor: | Phuong-Hien Nguyen, Nina Reinart, Maximilian Koch, Oleg Fedorchenko, Michael Hallek, Sebastian Reinartz, Tamina Seeger-Nukpezah, Natascha Rosen, Gero Knittel, Julia Saggau, Romy Barthel, Lisa Thelen, Hans Christian Reinhardt |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Genetically modified mouse Cancer Research Future studies Transgene Chronic lymphocytic leukemia sex difference Medizin lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases medicine adoptive transplantation TCL1 business.industry Brief Report Disease progression medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Transplantation Leukemia 030104 developmental biology transgenic mouse model Oncology 030220 oncology & carcinogenesis Meta-analysis Cancer research chronic lymphocytic leukemia business |
| Zdroj: | Cancers Cancers, Vol 12, Iss 1980, p 1980 (2020) |
| ISSN: | 2072-6694 |
| Popis: | The Eµ-TCL1 transgenic mouse model represents the most widely and extensively used animal model for chronic lymphocytic leukemia (CLL). In this report, we performed a meta-analysis of leukemia progression in over 300 individual Eµ-TCL1 transgenic mice and discovered a significantly accelerated disease progression in females compared to males. This difference is also reflected in an aggressive CLL mouse model with additional deletion of Tp53 besides the TCL1 transgene. Moreover, after serial adoptive transplantation of murine CLL cells, female recipients also succumbed to CLL earlier than male recipients. This sex-related disparity in the murine models is markedly contradictory to the human CLL condition. Thus, due to our observation we urge both careful consideration in the experimental design and accurate description of the Eµ-TCL1 transgenic cohorts in future studies. |
| Databáze: | OpenAIRE |
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