Chemoselective Reductive Aminations in Aqueous Nanoreactors Using Parts per Million Level Pd/C Catalysis

Autor:	Ruchita R. Thakore, Eugene S. Gao, Henry S. Jin, Gianluca Casotti, Balaram S. Takale, Bruce H. Lipshutz
Rok vydání:	2020
Předmět:	Aqueous solution 010405 organic chemistry Chemistry Organic Chemistry Imine Condensation Parts-per notation Nanoreactor 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Organic chemistry Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 22:6324-6329
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.0c02156
Popis:	Condensation in recyclable water between aldehydes or ketones and amines occurs smoothly within the hydrophobic cores of nanomicelles, resulting in imine formation that is subject to subsequent reduction leading, overall, to reductive amination. This micellar technology enables the synthesis of several types of pharmaceuticals, a new procedure that relies on only 2000 ppm (0.20 mol %) palladium from commercially available Pd/C. A broad range of substrates can be used under mild conditions, leading to high chemical yields of the desired secondary and tertiary amines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4d1dbb5282b6a29fce7c705df1492b https://doi.org/10.1021/acs.orglett.0c02156 Zobrazit plný text záznamu