Bioactive terpenes from Spongia officinalis
| Autor: | Emiliano Manzo, S. M. Abu Sayem, Margherita Gavagnin, Rob W. M. Van Soest, Guido Villani, Mario Varcamonti, M. Letizia Ciavatta |
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| Přispěvatelé: | Manzo, E, Ciavatta, Ml, Villani, G, Varcamonti, Mario, Sayem, Sm, van Soest, R, Gavagnin, M. |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Antifungal Agents
Sesterterpenes Stereochemistry Metabolite Pharmaceutical Science Pharmacognosy Analytical Chemistry Terpene chemistry.chemical_compound Drug Discovery Escherichia coli Animals Spongia officinalis Pharmacology Molecular Structure biology Terpenes J Nat Prod. 2011 May 27 Organic Chemistry Biological activity biology.organism_classification Spongia Anti-Bacterial Agents Porifera Sponge Complementary and alternative medicine chemistry Biofilms Molecular Medicine Marine natural products Sponges 74(5):1241-7 |
| Zdroj: | Journal of natural products 74 (2011): 1241–1247. doi:10.1021/np200226u info:cnr-pdr/source/autori:E. Manzo, M. L. Ciavatta, G. Villani, M. Varcamonti, S. M. Abu Sayem, R. van Soest and M. Gavagnin/titolo:Bioactive terpenes from Spongia officinalis/doi:10.1021%2Fnp200226u/rivista:Journal of natural products (Print)/anno:2011/pagina_da:1241/pagina_a:1247/intervallo_pagine:1241–1247/volume:74 |
| DOI: | 10.1021/np200226u |
| Popis: | The terpene metabolite pattern of Mediterranean Spongia officinalis was chemically investigated. This study resulted in the isolation of a series of sesterterpenes and C21 furanoterpenes, according to the literature data on this sponge. Four new oxidized minor metabolites (compounds 1, 2, 3, and 4) were isolated along with six known compounds of the furospongin series (compounds 5-8, 9, and 10) and three scalarane sesterterpenes (compounds 11-13). Interestingly, tetrahydrofurospongin-2 (6) and dihydrofurospongin-2 (7), which were among the main metabolites, induced biofilm formation by Escherichia coli. All compounds isolated were also assayed for antibacterial and antifungal properties. |
| Databáze: | OpenAIRE |
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