The administration of metoclopramide with atropine A drug interaction effect on the gastro?oesophageal sphincter in man
| Autor: | John G. Brock-Utne, M. G. Moshal, M. Naicker, G. E. Dimopoulos, John W. Downing, J. Rubin |
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| Rok vydání: | 1976 |
| Předmět: |
Adult
Atropine Adolescent Metoclopramide business.industry Reflux Middle Aged Drug interaction medicine.disease Gastric Content Basal (phylogenetics) Anesthesiology and Pain Medicine Pulmonary aspiration Gastro Anesthesia Injections Intravenous Pressure medicine Humans Drug Interactions Esophagogastric Junction business medicine.drug |
| Zdroj: | Anaesthesia. 31:1186-1190 |
| ISSN: | 1365-2044 0003-2409 |
| DOI: | 10.1111/j.1365-2044.1976.tb11970.x |
| Popis: | The effects of intravenous atropine 0-6 mg alone, metoclopramide (Maxolon) 10mg alone and atropine 0-6 mg and metoclopramide 10 mg in combination, on the lower oesophageal sphincter (LOS) were studied in three groups of normal human volunteers. Atropine decreased the LOS pressure by an average of 8 cm H2O (P less than 0-001), whereas metoclopramide increased the LOS pressure by a mean of 29 cmH2O compared to basal values (P less than 0-001). In contrast, no change in sphincter tone was noted following injection of atropine-metaclopramide mixture. These findings are relevant to the pre-operative preparation of patients presenting for emergency anaesthesia, since gasgro-oesophageal reflux and pulmonary aspiration of acid gastric content continues to be a significant cause of morbidity and mortality. |
| Databáze: | OpenAIRE |
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