Stereotactic radiosurgery for ablation of ventricular tachycardia
| Autor: | Jaroslav Januška, O Jiravsky, Jan Hecko, Martin Fiala, David Feltl, Petr Peichl, Jakub Cvek, Michal Kodaj, Radek Neuwirth, Lukas Knybel, Josef Kautzner, Lukas Molenda |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Catheter ablation 030204 cardiovascular system & hematology Radiosurgery Ventricular tachycardia 03 medical and health sciences 0302 clinical medicine Cyberknife Physiology (medical) Humans Medicine Aged business.industry Middle Aged Cardiac Ablation medicine.disease Ablation 3. Good health Catheter 030220 oncology & carcinogenesis Catheter Ablation Tachycardia Ventricular Antitachycardia Pacing Female Radiology Electrophysiologic Techniques Cardiac Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | EP Europace. 21:1088-1095 |
| ISSN: | 1532-2092 1099-5129 |
| Popis: | Aims Stereotactic body radiotherapy (SBRT) for ventricular tachycardias (VTs) could be an option after failed catheter ablation. In this study, we analysed the long-term efficacy and toxicity of SBRT applied as a bail-out procedure. Methods and results Patients with structural heart disease and unsuccessful catheter ablations for VTs underwent SBRT. The planning target volume (PTV) was accurately delineated using exported 3D electroanatomical maps with the delineated critical part of re-entry circuits. This was defined by detailed electroanatomic mapping and by pacing manoeuvres during the procedure. Using the implantable cardioverter-defibrillator lead as a surrogate contrast marker for respiratory movement compensation, 25 Gy was delivered to the PTV using CyberKnife. We evaluated occurrences of sustained VT, electrical storm, antitachycardia pacing, and shock; time to death; and radiation-induced events. From 2014 until March 2017, 10 patients underwent radiosurgical ablation (mean PTV, 22.15 mL; treatment duration, 68 min). After radiosurgery, four patients experienced nausea and one patient presented gradual progression of mitral regurgitation. During the follow-up (median 28 months), VT burden was reduced by 87.5% compared with baseline (P = 0.012) and three patients suffered non-arrhythmic deaths. After the blanking period, VT recurred in eight of 10 patients. The mean time to first antitachycardia pacing and shock were 6.5 and 21 months, respectively. Conclusion Stereotactic body radiotherapy appears to show long-term safety and effectiveness for VT ablation in structural heart disease inaccessible to catheter ablation. We report one possible radiation-related toxicity and promising overall survival, warranting evaluation in a prospective multicentre clinical trial. |
| Databáze: | OpenAIRE |
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