Novelty Determines the Effects of Olfactory Enrichment on Memory and Neurogenesis Through Noradrenergic Mechanisms
| Autor: | Véronique Nguyen, Joëlle Sacquet, Marc Marien, François Jourdan, Alexandra Veyrac, Anne Didier |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Serotonin Cell Survival Dopamine Neurogenesis Sensory system Olfaction Motor Activity Mice Norepinephrine Neuroplasticity Animals Labetalol Olfactory memory Cell Proliferation Pharmacology Environmental enrichment Novelty Olfactory Perception Olfactory Bulb Receptors Adrenergic Olfactory bulb Mice Inbred C57BL Psychiatry and Mental health Memory Short-Term Odorants Exploratory Behavior Psychology Neuroscience |
| Zdroj: | Neuropsychopharmacology. 34:786-795 |
| ISSN: | 1740-634X 0893-133X |
| DOI: | 10.1038/npp.2008.191 |
| Popis: | Commonly used experimental paradigms of environmental enrichment combine increased social interactions and sensory inputs and renewal of the objects present in the environment. However, the specific contribution of novelty to the effects of enrichment is unclear. Here, we show that repeated daily exposure to single novel odorants and not to an enriched but stable olfactory environment improves short-term olfactory memory and neurogenesis in the mouse olfactory bulb. In addition, these positive effects are mediated by noradrenalin as they are blocked by a noradrenergic receptor antagonist. These data suggest that novelty recognition and noradrenergic mechanisms are crucial in mediating neural plasticity induced by olfactory enrichment. |
| Databáze: | OpenAIRE |
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