Prognostic Value of c-Myc Immunohistochemical Expression in Muscle Invasive Urothelial Carcinoma of the Urinary Bladder: A Retrospective Study
| Autor: | Mahmoud I. Nassar, Tarek M. Elsaba, Amira Elwy, Ahmed Refaat Abd Elzaher |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Lymphovascular invasion medicine.medical_treatment muscle invasive Perineural invasion Metastasis Proto-Oncogene Proteins c-myc Cystectomy 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor Humans Medicine Neoplasm Invasiveness Survival analysis Aged Retrospective Studies Aged 80 and over Muscle Neoplasms Urinary bladder business.industry General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry Survival Rate c-Myc 030104 developmental biology medicine.anatomical_structure Urinary Bladder Neoplasms Tumor progression 030220 oncology & carcinogenesis Urothelial carcinoma Female business infiltrative pattern Research Article Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| Popis: | Objective: This study aimed to investigate the immunohistochemical expression of c-Myc in muscle invasive urothelial carcinoma (MIUC) of the urinary bladder and to evaluate the correlation of c-Myc expression with different clinicopathological parameters and outcome, including a relatively new histopathological tumor characteristic that is the growth pattern of tumor invasion. Methods: A total of 66 formalin-fixed and paraffin-embedded sections of MIUC obtained from radical cystectomy specimens were enrolled. The sections were stained with c-Myc antibody using immunohistochemistry technique. Results: Tumor cells showed variability in nuclear c-Myc expression according to the growth pattern of invasion. The median H-score of nuclear expression of infiltrative pattern was significantly higher than that of non-infiltrative pattern (p |
| Databáze: | OpenAIRE |
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