Localized inhibition in the Drosophila mushroom body
| Autor: | Eleftheria Vrontou, Hoger Amin, Raquel Suárez-Grimalt, Andrew C. Lin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cell physiology
0303 health sciences Interneuron Cell Stimulation Biology 03 medical and health sciences 0302 clinical medicine Calcium imaging medicine.anatomical_structure immune system diseases Mushroom bodies medicine Connectome neoplasms Neuroscience 030217 neurology & neurosurgery Function (biology) 030304 developmental biology |
| Zdroj: | bioRxiv |
| DOI: | 10.1101/2020.03.26.008300 |
| Popis: | Many neurons show compartmentalized activity, in which activity does not spread readily across the cell, allowing input and output to occur locally. However, the functional implications of compartmentalized activity for the wider neural circuit are often unclear. We addressed this problem in the Drosophila mushroom body, whose principal neurons, Kenyon cells, receive feedback inhibition from a large, non-spiking interneuron called APL. We used local stimulation and volumetric calcium imaging to show that APL inhibits Kenyon cells in both their dendrites and axons, and that both activity in APL and APL’s inhibitory effect on Kenyon cells are spatially localized, allowing APL to differentially inhibit different mushroom body compartments. Applying these results to the Drosophila hemibrain connectome predicts that individual Kenyon cells inhibit themselves via APL more strongly than they inhibit other individual Kenyon cells. These findings reveal how cellular physiology and detailed network anatomy can combine to influence circuit function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|