Relevant Physicochemical Methods to Functionalize, Purify, and Characterize Surface-Decorated Lipid-Based Nanocarriers
Autor: | Léna Guyon, Aurélie Malzert-Fréon, Anne-Claire Groo |
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Přispěvatelé: | Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU) |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Pharmaceutical Science
Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Drug Delivery Systems Drug Discovery Animals Humans Purification methods ComputingMilieux_MISCELLANEOUS Targeting ligands Drug Carriers Ligand Chemistry Isothermal titration calorimetry 021001 nanoscience & nanotechnology Lipids 0104 chemical sciences Nanomedicine [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology Nanoparticles Molecular Medicine Surface modification Nanocarriers 0210 nano-technology |
Zdroj: | Molecular Pharmaceutics Molecular Pharmaceutics, American Chemical Society, 2021, 18 (1), pp.44-64. ⟨10.1021/acs.molpharmaceut.0c00857⟩ |
ISSN: | 1543-8384 1543-8392 |
Popis: | Surface functionalization of lipid-based nanocarriers (LBNCs) with targeting ligands has attracted huge interest in the field of nanomedicines for their ability to overcome some physiological barriers and their potential to deliver an active molecule to a specific target without causing damage to healthy tissues. The principal objective of this review is to summarize the present knowledge on LBNC decoration used for biomedical applications, with an emphasis on the ligands used, the functionalization approaches, and the purification methods after ligand corona formation. The most potent experimental techniques for the LBNC surface characterization are described. The potential of promising methods such as nuclear magnetic resonance spectroscopy and isothermal titration calorimetry to characterize ligand surface corona is also outlined. |
Databáze: | OpenAIRE |
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