Impaired fornix-hippocampus integrity is linked to peripheral glutathione peroxidase in early psychosis
| Autor: | Michel Cuenod, Carina Ferrari, Luis Alameda, Philippe Conus, Philippe Golay, Pierre Baumann, Patric Hagmann, Margot Fournier, Alessandra Griffa, Kim Q. Do, Jean-Philippe Thiran |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Bipolar Disorder Fornix Brain Hippocampus Hippocampal formation medicine.disease_cause chemistry.chemical_compound 0302 clinical medicine Image Processing Computer-Assisted chemistry.chemical_classification Glutathione peroxidase Fornix Organ Size Glutathione Magnetic Resonance Imaging 3. Good health Psychiatry and Mental health Diffusion Tensor Imaging Original Article Female Adult Anisotropy Bipolar Disorder/blood Bipolar Disorder/diagnostic imaging Bipolar Disorder/pathology Case-Control Studies Depressive Disorder Major/blood Depressive Disorder Major/diagnostic imaging Depressive Disorder Major/pathology Fornix Brain/diagnostic imaging Fornix Brain/pathology Glutathione/blood Glutathione Peroxidase/blood Hippocampus/diagnostic imaging Hippocampus/pathology Humans Oxidative Stress Psychotic Disorders/blood Psychotic Disorders/diagnostic imaging Psychotic Disorders/pathology Schizophrenia/blood Schizophrenia/diagnostic imaging Schizophrenia/pathology Young Adult medicine.medical_specialty Psychosis 03 medical and health sciences Cellular and Molecular Neuroscience Internal medicine Fractional anisotropy medicine Biological Psychiatry Depressive Disorder Major Glutathione Peroxidase business.industry medicine.disease eye diseases 030227 psychiatry Endocrinology Psychotic Disorders chemistry nervous system Schizophrenia sense organs business Neuroscience 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Translational psychiatry, vol. 6, no. 7, pp. e859 Translational Psychiatry ResearcherID |
| Popis: | Several lines of evidence implicate the fornix–hippocampus circuit in schizophrenia. In early-phase psychosis, this circuit has not been extensively investigated and the underlying mechanisms affecting the circuit are unknown. The hippocampus and fornix are vulnerable to oxidative stress at peripuberty in a glutathione (GSH)-deficient animal model. The purposes of the current study were to assess the integrity of the fornix–hippocampus circuit in early-psychosis patients (EP), and to study its relationship with peripheral redox markers. Diffusion spectrum imaging and T1-weighted magnetic resonance imaging (MRI) were used to assess the fornix and hippocampus in 42 EP patients compared with 42 gender- and age-matched healthy controls. Generalized fractional anisotropy (gFA) and volumetric properties were used to measure fornix and hippocampal integrity, respectively. Correlation analysis was used to quantify the relationship of gFA in the fornix and hippocampal volume, with blood GSH levels and glutathione peroxidase (GPx) activity. Patients compared with controls exhibited lower gFA in the fornix as well as smaller volume in the hippocampus. In EP, but not in controls, smaller hippocampal volume was associated with high GPx activity. Disruption of the fornix–hippocampus circuit is already present in the early stages of psychosis. Higher blood GPx activity is associated with smaller hippocampal volume, which may support a role of oxidative stress in disease mechanisms. |
| Databáze: | OpenAIRE |
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