Myoblast and Fibroblast Therapy for Post-Prostatectomy Urinary Incontinence: 1-Year Followup of 63 Patients
| Autor: | Eva Margreiter, Michael Mitterberger, Hanno Ulmer, Rainer Marksteiner, Georg Bartsch, Hannes Strasser, Ferdinand Frauscher, Martin Fussenegger, Germar M. Pinggera |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Nephrology medicine.medical_specialty Time Factors Myoblasts Skeletal Urology medicine.medical_treatment Urinary incontinence Injections Contractility Quality of life Internal medicine medicine Humans Aged Ultrasonography Aged 80 and over Prostatectomy medicine.diagnostic_test business.industry Fibroblasts Middle Aged Surgery Endoscopy Urinary Incontinence Urethra medicine.anatomical_structure Rhabdosphincter medicine.symptom business Follow-Up Studies |
| Zdroj: | Journal of Urology. 179:226-231 |
| ISSN: | 1527-3792 0022-5347 |
| Popis: | We assessed the efficacy and safety of the application of autologous fibroblasts and myoblasts for treatment in post-prostatectomy urinary incontinence after a minimal followup of 1 year.Sixty-three patients with stress urinary incontinence after radical prostatectomy were treated with transurethral ultrasound guided injections of autologous fibroblasts and myoblasts obtained from skeletal muscle biopsies. All subjects were evaluated preoperatively and 12 months postoperatively in terms of incontinence and Quality of Life Instrument scores, urodynamic parameters, and morphology and function of the urethra and rhabdosphincter.Of the 63 patients 41 were continent 12 months after implantation of cells, 17 showed improvement and 5 did not show any improvement. Incontinence and Quality of Life Instrument scores as well as thickness and contractility of the rhabdosphincter were significantly improved postoperatively.The use of myoblast and fibroblast therapy represents a minimally invasive, safe and effective treatment for post-prostatectomy incontinence after a followup of 1 year. |
| Databáze: | OpenAIRE |
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