Function and mechanism of CNTF/LIF signaling in retinogenesis
| Autor: | Kun Do Rhee, Xian-Jie Yang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
endocrine system
Retinal Bipolar Cells Cellular differentiation Organogenesis Ciliary neurotrophic factor Leukemia Inhibitory Factor Retina Article Mice medicine Animals Ciliary Neurotrophic Factor reproductive and urinary physiology Cell Proliferation biology Stem Cells Gene Expression Regulation Developmental Cell Differentiation Glycoprotein 130 biological factors Cell biology Ion homeostasis medicine.anatomical_structure embryonic structures biology.protein STAT protein Signal transduction Muller glia Leukemia inhibitory factor hormones hormone substitutes and hormone antagonists Photoreceptor Cells Vertebrate Signal Transduction |
| Zdroj: | Retinal Degenerative Diseases ISBN: 9781441913982 |
| ISSN: | 0065-2598 |
| Popis: | Ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) exhibit multiple biological effects in the developing vertebrate retina. CNTF/LIF inhibits rod photoreceptor, and promotes bipolar cells and Muller glia differentiation. In addition, CNTF/LIF has been shown to have proliferative and apoptotic effects. Moreover, LIF also inhibits retinal vascular development. CNTF/LIF signaling components CNTFRalpha, LIFRbeta, gp130, and a number of STAT proteins are expressed in the retina. CNTF/LIF activates Jak-STAT, ERK, and Notch pathways during retinal development. Perturbation of CNTF induced signal transduction reveals that different combinations of CNTF/LIF signaling pathways regulate differentiation of retinal neurons and glia. Gene expression studies show that CNTF/LIF affects retinogenesis by regulating various genes involved in transcription, signal transduction, protein modification, apoptosis, protein localization, and cell ion homeostasis. Most past studies have deployed ectopic expression or addition of exogenous CNTF/LIF, thus further ana-lysis of mice with conditional mutations in CNTF/LIF signaling components will allow better understanding of in-vivo functions of CNTF/LIF associated signaling events in retinogenesis. |
| Databáze: | OpenAIRE |
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