The role of IL‐3 in bone
| Autor: | Neil Alles, Niroshani S. Soysa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
business.industry medicine.medical_treatment Osteoblast Cell Biology Bone Marrow Aplasia medicine.disease Biochemistry 03 medical and health sciences Haematopoiesis 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Cytokine Osteoclast 030220 oncology & carcinogenesis Rheumatoid arthritis Bone cell medicine Cancer research business Molecular Biology Multiple myeloma |
| Zdroj: | Journal of Cellular Biochemistry. 120:6851-6859 |
| ISSN: | 1097-4644 0730-2312 |
| DOI: | 10.1002/jcb.27956 |
| Popis: | In the recent past, there has been a burgeoning interest in targeting cytokines such as IL-3 for specific disease conditions of bone such as rheumatoid arthritis and multiple myeloma. Unlike other cytokines, IL-3 is a cytokine with a multilineage potential and broad spectrum of target cells and it plays a vital role in hematopoiesis. Due to its common receptor subunit, the action of IL-3 shows functional redundancy with other cytokines such as the granulocyte-macrophage colony-stimulating factor and IL-5. IL-3 has been successfully used in ameliorating radiation-induced bone marrow aplasia and similar conditions. However, the role of IL-3 in bone cells has not been fully unraveled yet; therefore, the aim of this overview is to present the effects of IL-3 in bone with a special emphasis on osteoclasts and osteoblasts in a concise manner. |
| Databáze: | OpenAIRE |
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