Estimation of serum neopterin in patients with acute coronary syndrome
| Autor: | Sai Babu, Kotturathu Mammen Cherian, Rama Krishna Reddy Yeruva, Prema Gurumurthy, Joy M. Thomas, Sai Krishna Borra |
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| Rok vydání: | 2013 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Acute coronary syndrome Myocardial Infarction Inflammation Systemic inflammation Neopterin chemistry.chemical_compound Immune system Predictive Value of Tests Interferon Internal medicine medicine Creatine Kinase MB Form Humans Angina Unstable Myocardial infarction Acute Coronary Syndrome Chromatography High Pressure Liquid business.industry Unstable angina Troponin I General Medicine medicine.disease Up-Regulation chemistry Case-Control Studies Cardiology Surgery Inflammation Mediators medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers medicine.drug |
| Zdroj: | Asian Cardiovascular and Thoracic Annals. 21:426-431 |
| ISSN: | 1816-5370 0218-4923 |
| Popis: | Background: The aim of our study was to determine neopterin levels in patients with acute coronary syndrome, in which the release of various cytokines activates the cellular immune system. There is an increase in the number and activity of T-cells in unstable atherosclerotic plaques, and of type 1 helper T-cells that produce interferon γ, which in turn produces neopterin, a byproduct of the guanosine triphosphate-biopterin pathway and a marker for activated macrophages. Methods: We studied 600 subjects consisting of healthy volunteers and patients with noncardiac chest pain, ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, or unstable angina. Neopterin levels were determined by high-performance liquid chromatography. Results: Mean serum neopterin levels in ST-segment elevation myocardial infarction (11.5 ± 3.2 nmol·L−1), non-ST-segment elevation myocardial infarction (9.8 ± 2.9 nmol·L−1), and unstable angina patients (9.4 ± 2.3 nmol·L−1) were significantly higher than those in noncardiac chest pain patients (7.4 ± 1.9 nmol·L−1) and healthy volunteers (7.2 ± 0.6 nmol·L−1; p Conclusion: These findings suggest that serum neopterin levels may be a useful marker of systemic inflammation, and measurement of serum neopterin may be helpful in assessing the risk of developing coronary heart disease. |
| Databáze: | OpenAIRE |
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