Design and synthesis of new potent human cytomegalovirus (HCMV) inhibitors based on internally hydrogen-bonded 1,6-naphthyridines

Autor:	Guy Falardeau, Laval Chan, Tomislav Stefanac, Jean-François Lavallée, Suzanne May, Jean Bedard, Haolun Jin
Rok vydání:	2001
Předmět:	Human cytomegalovirus Cell Survival Stereochemistry Clinical Biochemistry Cytomegalovirus Pharmaceutical Science Naphthalenes Antiviral Agents Biochemistry Chemical synthesis Inhibitory Concentration 50 Structure-Activity Relationship chemistry.chemical_compound Amide Drug Discovery medicine Moiety Naphthyridines Cytotoxicity Molecular Biology Bicyclic molecule Hydrogen bond Chemistry Organic Chemistry Hydrogen Bonding Biological activity medicine.disease Thioamides Drug Design Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 11:103-105
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(00)00607-7
Popis:	1,6-Naphthyridine-2-carboxylic acid benzylamides are potent anti-HCMV compounds. Replacement of the amide moiety by other groups containing internal hydrogen bonds was undertaken to extend the SAR. Our results indicated that the urca derivatives showed very good activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce08a09a3b6fa1549479816ca26c846 https://doi.org/10.1016/s0960-894x(00)00607-7 Zobrazit plný text záznamu Full Text from ScienceDirect