SPECIFIC STIMULATION OF MIGRATION OF HUMAN KERATINOCYTES BY μ -OPIATE RECEPTOR AGONISTS
| Autor: | Stanislaus Büchner, Mei Bigliardi-Qi, Paul L. Bigliardi, Theo Rufli |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Keratinocytes
Narcotics medicine.medical_specialty medicine.drug_class Narcotic Antagonists Receptors Opioid mu Stimulation Dynorphin In Vitro Techniques Pharmacology Ligands Biochemistry Cell Movement Internal medicine medicine Humans Regeneration Keratinocyte migration Receptor Opioid peptide Molecular Biology Cells Cultured Skin Wound Healing business.industry beta-Endorphin Granulation tissue Cell Biology Receptor antagonist Naltrexone medicine.anatomical_structure Endocrinology business Wound healing |
| Zdroj: | Journal of Receptors and Signal Transduction. 22:191-199 |
| ISSN: | 1532-4281 1079-9893 |
| Popis: | There are several indications that neuropeptides, especially the opiate receptor agonists, modulate the immune response by stimulating the formation of granulation tissue and enhancing the reepithelialization. We observed that the mu-opiate receptor ligand beta-endorphin stimulates the migration of cultured human foreskin keratinocytes. After 1 hour exposure to 1 microM beta-endorphin, the keratinocytes experienced an increase of cell diameter by cellular elongation and stimulation of migration. Dynorphin had a lesser effect under the same condition. The opiate receptor antagonist naltrexone significantly reduced the effect of beta-endorphin on keratinocyte migration. This migratory effect of mu-opiate receptor agonists in vitro indicates that the opioid peptides, released in wounds, could play a key role in the final reepithelialization and tissue regeneration in wound healing. This new knowledge will help us not only to understand the mechanism of wound healing but also to improve the therapeutic strategy in the healing of painful chronic wounds. |
| Databáze: | OpenAIRE |
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