Reconstructed and real proton radiographs for image-guidance in proton beam therapy
| Autor: | Don F. DeJongh, James S. Welsh, Mark Pankuch, Chelsea J. Miller, Caesar E. Ordoñez, John R. Winans, Basel Altoos, George Coutrakon, Ethan A. DeJongh, Nicholas T. Karonis, V. Rykalin |
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| Rok vydání: | 2019 |
| Předmět: |
Range (particle radiation)
Proton business.industry medicine.medical_treatment Radiography Physics::Medical Physics Planning target volume Article 030218 nuclear medicine & medical imaging Radiation therapy 03 medical and health sciences 0302 clinical medicine Optics 030220 oncology & carcinogenesis Physics::Accelerator Physics Medicine business Image guidance Particle beam Beam (structure) |
| Zdroj: | J Radiat Oncol |
| ISSN: | 1948-7908 1948-7894 |
| DOI: | 10.1007/s13566-019-00376-0 |
| Popis: | One of the major challenges to proton beam therapy at this time is the uncertainty of the true range of a clinical treatment proton beam as it traverses the various tissues and organs in a human body. This uncertainty necessitates the addition of greater “margins” to the planning target volume along the direction of the beam to ensure safety and tumor target coverage. Proton radiography holds promise as both an image-guidance method for proton beam therapy and as a means of estimating particle beam range in the clinic. In this brief report, we present some of the first real and reconstructed proton radiographs using our particular system. Our qualitative review of these images indicates that this method has excellent potential as a proton radiography-based image guidance system. Based on the encouraging results of our preliminary work, more rigorous and quantitative analyses will be performed shortly and we shall continue to explore the potential of this approach for addressing the particle beam range uncertainty issue. |
| Databáze: | OpenAIRE |
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