Liver Cirrhosis: Intravoxel Incoherent Motion MR Imaging—Pilot Study
| Autor: | Alain Luciani, Alain Rahmouni, Alexandre Vignaud, Pierre Brugières, Ariane Mallat, Jean-François Deux, Madeleine Cavet, Jeanne Tran Van Nhieu, Alexis Laurent, Lucile Ruel |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Liver Cirrhosis Male Cirrhosis Pilot Projects Chronic liver disease In vivo medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging Intravoxel incoherent motion Aged Retrospective Studies medicine.diagnostic_test Phantoms Imaging business.industry Magnetic resonance imaging Middle Aged medicine.disease Mr imaging Diffusion Magnetic Resonance Imaging Liver Female Nuclear medicine business Perfusion |
| Zdroj: | Radiology. 249:891-899 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiol.2493080080 |
| Popis: | Purpose To retrospectively evaluate a respiratory-triggered diffusion-weighted (DW) magnetic resonance (MR) imaging sequence combined with parallel acquisition to allow the calculation of pure molecular-based (D) and perfusion-related (D*, f) diffusion parameters, on the basis of the intravoxel incoherent motion (IVIM) theory, to determine if these parameters differ between patients with cirrhosis and patients without liver fibrosis. Materials and methods The institutional review board approved this retrospective study; informed consent was waived. IVIM DW imaging was tested on three alkane phantoms, on which the signal-intensity decay curves according to b factors were logarithmically plotted. Ten b factors (0, 10, 20, 30, 50, 80, 100, 200, 400, 800 sec/mm(2)) were used in patients. Patients with documented liver cirrhosis (cirrhotic liver group, n = 12) and patients without chronic liver disease (healthy liver group, n = 25) were included. The mean liver D, D*, and f values were measured and compared with the apparent diffusion coefficient (ADC) computed by using four b values (0, 200, 400, 800 sec/mm(2)). Liver ADC and D, f, and D* parameters were compared between the cirrhotic liver group and healthy liver group. Means were compared by using the Student t test. Results Signal-intensity decay curves were monoexponential on phantoms and biexponential in patients. In vivo, mean ADC values were significantly higher than D in the healthy liver group (ADC = 1.39 x 10(-3) mm(2)/sec +/- 0.2 [standard deviation] vs D = 1.10 x 10(-3) mm(2)/sec +/- 0.7) and in the cirrhotic liver group (ADC = 1.23 x 10(-3) mm(2)/sec +/- 0.4 vs D = 1.19 x 10(-3) mm(2)/sec +/- 0.5) (P = .03). ADC and D* were significantly reduced in the cirrhotic liver group compared with those in the healthy liver group (respective P values of .03 and .008). Conclusion Restricted diffusion observed in patients with cirrhosis may be related to D* variations, which reflect decreased perfusion, as well as alterations in pure molecular water diffusion in cirrhotic livers. |
| Databáze: | OpenAIRE |
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