The interaction between resistance modifiers such as pyrido[3,2-g]quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA
| Autor: | Andreas Hilgeroth, Gabriella Spengler, János Kiss, Annamária Molnár, Sandrine Gallo, Abdallah Mahamoud, J. Szabo, Joseph Molnár, Derek Sharples, Zsuzsanna Antal, Jacques Barbe |
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| Rok vydání: | 2004 |
| Předmět: |
Antineoplastic Agents
chemistry.chemical_compound Plasmid RNA Transfer Cell Line Tumor Drug Discovery Humans Drug Interactions ATP Binding Cassette Transporter Subfamily B Member 1 neoplasms Pharmacology Fluorenes biology Dose-Response Relationship Drug Molecular Structure Chemistry Organic Chemistry Quinoline Pregnane General Medicine DNA biology.organism_classification Pregnanes Biochemistry Cell culture Drug Resistance Neoplasm Transfer RNA Cancer cell Quinolines Genes MDR Bacteria Plasmids |
| Zdroj: | European journal of medicinal chemistry. 40(2) |
| ISSN: | 0223-5234 |
| Popis: | Various resistance mechanisms such as complex formation with DNA, tRNA and MDR1 p-glycoprotein were modified in bacteria and cancer cells in presence of pregnane, pyridoquinoline, and aza-oxafluorene derivatives. Interaction between the compounds, plasmid DNA and tRNA was shown and compared to the interaction with calf thymus DNA. Complex formation with MDR1 p-glycoprotein and drug accumulation increased in cancer cells. Both plasmid DNA and p-gp complex formation were related to the chemical structures of the resistance modifiers. |
| Databáze: | OpenAIRE |
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