Deletions in the dystrophin gene: analysis of Duchenne and Becker muscular dystrophy patients in Quebec
| Autor: | Louise R. Simard, Delvoye N, Michel Vanasse, Serge B. Melançon, Damian Labuda, F Gingras |
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| Rok vydání: | 1992 |
| Předmět: |
musculoskeletal diseases
Adult Male congenital hereditary and neonatal diseases and abnormalities X Chromosome Adolescent Duchenne muscular dystrophy Population Muscular Dystrophies Dystrophin Exon Genetics medicine Humans Muscular dystrophy education Child Genetics (clinical) education.field_of_study biology Breakpoint Intron Quebec Infant musculoskeletal system medicine.disease Open reading frame Blotting Southern Child Preschool biology.protein Chromosome Deletion |
| Zdroj: | Human genetics. 89(4) |
| ISSN: | 0340-6717 |
| Popis: | We have analyzed patient DNA samples in 77 unrelated Duchenne (DMD) and Becker (BMD) muscular dystrophy families, 73 of which were of French Canadian origin. We show that the frequency (68%) and distribution of deletions within the dystrophin gene was neither random nor unique in this population. We localized 33% of the deletions to the proximal portion of the dystrophin gene while 63% involved the exons spanning introns 43 through 55 with breakpoint clusters occurring within introns 44 and 50. Whether the dystrophin open reading frame (ORF) is maintained constrains the distribution of DMD/BMD deletions such that BMD deletions tend to be strikingly homogeneous. Finally, the conservation of the dystrophin ORF and the severity of the clinical phenotype were concordant in 95% of the DMD/BMD deletions documented by this work. |
| Databáze: | OpenAIRE |
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