Surgery Significantly Improves Neurocognition, Sleep, and Blood Pressure in Primary Hyperparathyroidism: A 3-Year Prospective Follow-Up Study

Autor: Harri Sintonen, Eeva Ryhänen, Risto P. Roine, Ilkka Heiskanen, Sara Storvall, Camilla Schalin-Jäntti
Rok vydání: 2017
Předmět:
Adult
Male
Parathyroidectomy
medicine.medical_specialty
Sexual Behavior
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Clinical Biochemistry
Population
Blood Pressure
030209 endocrinology & metabolism
Biochemistry
03 medical and health sciences
Cognition
0302 clinical medicine
Endocrinology
Quality of life
Surveys and Questionnaires
Internal medicine
Humans
Medicine
Prospective Studies
Prospective cohort study
education
Antihypertensive Agents
Aged
Aged
80 and over
Hyperparathyroidism
education.field_of_study
business.industry
Biochemistry (medical)
General Medicine
Middle Aged
Hyperparathyroidism
Primary
medicine.disease
3. Good health
Surgery
Blood pressure
030220 oncology & carcinogenesis
Cohort
Quality of Life
Female
Sleep
business
Primary hyperparathyroidism
Follow-Up Studies
Zdroj: Hormone and Metabolic Research. 49:772-777
ISSN: 1439-4286
0018-5043
DOI: 10.1055/s-0043-118347
Popis: Surgery for primary hyperparathyroidism (PHPT) improves health-related quality of life (HRQoL), but it is unclear whether the effects are sustained after medium-term (>2 years) follow-up, and whether the results on some or all dimensions of HRQoL will reach that of the general population. We performed a follow-up of HRQoL on average 3.3 years after surgery for PHPT using the 15D in our patient cohort (n=124) and compared the results to those of an age- and gender-standardized general population (n=1099). We studied self-reported blood pressure and current medications; new comorbidities were retrieved from electronic patient records. A total of 104 (83%) patients [eight with serum calcium (1.34–1.46 mmol/l)] returned the questionnaires. After a follow-up of 3.3 years (range 23 to 55 months), systolic and diastolic blood pressure had decreased significantly compared to baseline (the situation before surgery, p2 years follow-up, surgery improves blood pressure and restores neurocognitive function and sleep to the level of the general population. The improvements observed in overall HRQoL at one year after surgery are sustained, but overall HRQoL does not reach that of the general population.
Databáze: OpenAIRE
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