| Přispěvatelé: |
Sardu, Celestino, Gatta, Gianluca, Pieretti, Gorizio, Onofrio, Nunzia D', Balestrieri, Maria Luisa, Scisciola, Lucia, Cappabianca, Salvatore, Ferraro, Giuseppe, Nicoletti, Giovanni Francesco, Signoriello, Giuseppe, Sportiello, Liberata, Savarese, Gianluigi, Melchionna, Mario, Ciccarelli, Feliciano, La Forgia, Daniele, Paolisso, Giuseppe, Marfella, Raffaele |
| Popis: |
Objectives: To evaluate the expression of sodium-glucose transporter 2 (SGLT2), inflammatory cytokines, and sirtuins in breast fat tissue at baseline, and serum cytokines of fatty vs. non-fatty pre-menopausal women at baseline, and at 12 months of follow-up. To correlate SGLT2/cytokines/sirtuins expression to clinical variables, and their changes (Δ) at follow-up, as intima-media wall thickness (IMT), left ventricle mass (LVM), left ventricle ejection fraction (LVEF), and myocardial performance index (MPI), and its normalization. Background: Pre-menopausal women with the lowest breast fat density (fatty breast) vs. higher breast fat density (non-fatty breast) are a high-risk population for cardiovascular diseases and worse prognosis. Methods: We analyzed SGLT2/cytokines/sirtuins of excised fatty breasts of fatty vs. non-fatty pre-menopausal women. We correlated SGLT2/cytokines/sirtuins to Δ IMT, Δ LVM, Δ LVEF, and Δ MPI, and normal cardiac performance (NCP) at 1 year of follow-up. Results: fatty vs. non-fatty breast over-expressed SGLT2/inflammatory cytokines, with lowest values of sirtuins (p |
