Validation and Extension Study Exploring the Role of RNF213 p.R4810K in 2,877 Chinese Moyamoya Disease Patients
| Autor: | Wanyang Liu, Fangfang Nie, Fanxin Zeng, Cong Han, Na Ta, Zhibin Yang, Hui Wang, Lanxin Ou, Mengke Shang, Desheng Li, Xiang-Yang Bao, Xiaotong Wang, Man Liang, Fangbin Hao, Zheng-Shan Zhang, Yuetian Yang, Lian Duan, Rimiao Yang, Yue Wang, Zhengxing Zou |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male China Pediatrics medicine.medical_specialty Ubiquitin-Protein Ligases Geographic proximity Affect (psychology) Chart review medicine Humans Genetic Predisposition to Disease Moyamoya disease Family history Child Retrospective Studies Adenosine Triphosphatases Adult patients business.industry Extension study Incidence (epidemiology) Rehabilitation medicine.disease Phenotype Female Surgery Neurology (clinical) Moyamoya Disease Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Stroke and Cerebrovascular Diseases. 30:106071 |
| ISSN: | 1052-3057 |
| DOI: | 10.1016/j.jstrokecerebrovasdis.2021.106071 |
| Popis: | To validate, update, and extend the role of RNF213 p.R4810K (GA) for predicting the phenotype of moyamoya disease (MMD) patients and explore the different effects on pediatric and adult groups.A total of 2,877 patients conducted from 2004 to 2018 were included. Review Manage 5.3 and SPSS 20.0 were applied to complete all statistical analyses. Information on age at onset, sex, initial symptom, family history and complications were obtained via retrospective chart review. Angiographic records were evaluated.In China, geographic proximity to Korea or Japan may affect the carrying rate of RNF213 p.R4810K. The proportion of patients with the following characteristics was significantly higher (P0.017) in the GA than in the GG group: female, age at onset18 years, infarct after transient ischemic attack, family history of MMD, and posterior cerebral artery involvement. For pediatric patients, GA showed more cerebral hemorrhage (CH) (odds ratios (ORs) [95% confidence intervals (CIs)] = 3.99 (1.61-9.88), P = 0.003), more patients were in the Suzuki early and intermediate stage (P = 0.001; P = 0.001, respectively), while for the adult group, GA indicated more female (OR [95% CIs] = 1.43 [1.15-1.79], P = 0.001), fewer patients with diabetes (0.58 [0.38-0.86], P = 0.007) and intermediate Suzuki stage (P = 3.70 × 10The incidence and carrying rates of RNF213 p.R4810K in various regions for Chinese MMD patients were obviously different. RNF213 p.R4810K has different predictive effects on phenotypes of pediatric and adult patients. |
| Databáze: | OpenAIRE |
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