Tunicate-Inspired Gallic Acid/Metal Ion Complex for Instant and Efficient Treatment of Dentin Hypersensitivity
| Autor: | Naresh D. Sanandiya, Dong Soo Hwang, Ekavianty Prajatelistia, Sang Ho Jun, Sung-Won Ju, Jin-Soo Ahn |
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| Rok vydání: | 2016 |
| Předmět: |
Periodontal Ligament
Metal ions in aqueous solution Biomedical Engineering Pharmaceutical Science Dentistry 02 engineering and technology Pyrogallol 010402 general chemistry 01 natural sciences Biomaterials Metal chemistry.chemical_compound stomatognathic system Gallic Acid medicine Animals Humans Urochordata Gallic acid Ions Enamel paint biology business.industry Dentin Sensitivity 021001 nanoscience & nanotechnology biology.organism_classification medicine.disease 0104 chemical sciences Tunicate stomatognathic diseases Durapatite Dentinal Tubule chemistry Metals Tooth Remineralization visual_art visual_art.visual_art_medium Dentin hypersensitivity Rheology 0210 nano-technology business Tooth Nuclear chemistry |
| Zdroj: | Advanced Healthcare Materials. 5:919-927 |
| ISSN: | 2192-2640 |
| DOI: | 10.1002/adhm.201500878 |
| Popis: | Dentin hypersensitivity is sharp and unpleasant pains caused by exposed dentinal tubules when enamel outside of the tooth wears away. The occlusion of dentinal tubules via in situ remineralization of hydroxyapatite is the best method to alleviate the symptoms caused by dentin hypersensitivity. Commercially available dental desensitizers are generally effective only on a specific area and are relatively toxic, and their performance usually depends on the skill of the clinician. Here, a facile and efficient dentin hypersensitivity treatment with remarkable aesthetic improvement inspired by the tunicate-self-healing process is reported. As pyrogallol groups in tunicate proteins conjugate with metal ions to heal the torn body armor of a tunicate, the ingenious mechanism by introducing gallic acid (GA) as a cheap, abundant, and edible alternative to the pyrogallol groups of the tunicate combined with a varied daily intake of metal ion sources is mimicked. In particular, the GA/Fe(3+) complex exhibits the most promising results, to the instant ≈52% blockage in tubules within 4 min and ≈87% after 7 d of immersion in artificial saliva. Overall, the GA/metal ion complex-mediated coating is facile, instant, and effective, and is suggested as an aesthetic solution for treating dentin hypersensitivity. |
| Databáze: | OpenAIRE |
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