Reduction of hibernation bout duration by intraventricular infusion of met-enkephalin
| Autor: | Alexander L. Beckman, Carmen Llados-Eckman, Toni L. Stanton |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Met-enkephalin Hibernation endocrine system medicine.medical_specialty Enkephalin Methionine Central nervous system Neuropeptide chemistry.chemical_compound Bout duration Internal medicine medicine Animals Opioid peptide Ground squirrel Molecular Biology Injections Intraventricular Dose-Response Relationship Drug biology General Neuroscience Sciuridae biology.organism_classification Endocrinology medicine.anatomical_structure chemistry Ventricle Female Neurology (clinical) human activities Developmental Biology |
| Zdroj: | Brain Research. 588:159-163 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(92)91357-k |
| Popis: | The potential of brain met-enkephalin (met-enk) systems to modulate central nervous system (CNS) activity during periods of general depression (modeled by the mammalian hibernation state) was studied in the ground squirrel (Citellus lateralis). Following entrance into hibernation, continuous met-enk infusion into the lateral ventricle (1 microliter/h; 0.2, 1 and 5 micrograms/microliter) produced a dose-dependent reduction in bout duration ranging from 1.2 to 3.9 days (13.8-44.6% of baseline bout duration). We suggest that the activity of met-enk-releasing neurons may serve to increase the excitability of the depressed CNS, thus accelerating the termination of the hibernation bout. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|