Excitation of prefrontal cortical neurons during conditioning enhances fear memory formation
Autor: | Yuki Kobayashi, Mio Yamazaki, Natsumi Shibano, Yoshitake Sano, Tomoki Arima, Teiichi Furuichi, Marin Kuroda, Konami Abe, Shigeyoshi Itohara |
---|---|
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male Conditioning Classical Hippocampus lcsh:Medicine Prefrontal Cortex Fear conditioning Engram Biology Amygdala Article Learning and memory 03 medical and health sciences Mice 0302 clinical medicine Memory medicine Premovement neuronal activity Animals Humans Prefrontal cortex lcsh:Science Neurons Receptor Muscarinic M3 Emotion Multidisciplinary Basolateral Nuclear Complex lcsh:R Cognitive neuroscience Fear Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure nervous system lcsh:Q Neuroscience Immediate early gene Proto-Oncogene Proteins c-fos 030217 neurology & neurosurgery Basolateral amygdala |
Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
ISSN: | 2045-2322 |
Popis: | Animals can remember a situation associated with an aversive event. Contextual fear memory is initially encoded and consolidated in the hippocampus and gradually consolidated in multiple brain regions over time, including the medial prefrontal cortex (PFC). However, it is not fully understood how PFC neurons contribute to contextual fear memory formation during learning. In the present study, neuronal activity was increased in PFC neurons utilizing the pharmacogenetic hM3Dq-system in male mice. We show that fear expression and memory formation are enhanced by increasing neuronal activity in PFC during conditioning phase. Previous studies showed that the activation of hM3Dq receptor in a subset of amygdala neurons enhanced fear memory formation and biased which neurons are allocated to a memory trace, in which immediate early gene c-fos was preferentially expressed following memory retrieval in these pre-activated neurons. In this study, hM3Dq activation in PFC could not change the probability of c-fos expression in pre-activated neurons flowing memory retrieval. Instead, the number c-fos positive neurons following memory retrieval was significantly increased in the basolateral amygdala. Our results suggest that neuronal activity in PFC at the time of learning modulates fear memory formation and downstream cellular activity at an early phase. |
Databáze: | OpenAIRE |
Externí odkaz: |