Cytotoxic alkylpiperidine alkaloids from the Brazilian marine sponge Pachychalina alcaloidifera

Autor:	Manoel Odorico de Moraes, Eduardo Hajdu, Jaine H. H. L. de Oliveira, Antonio G. Ferreira, A. M. Nascimento, Mario L. Macedo, Ulisses Pinheiro, R. G. S. Berlinck, Miriam H. Kossuga, Claudia do Ó Pessoa, Bruno C. Cavalcanti
Rok vydání:	2007
Předmět:	Stereochemistry Pharmaceutical Science Antineoplastic Agents Marine Biology Pharmacognosy Analytical Chemistry Alkaloids Piperidines Drug Discovery Cytotoxic T cell Animals Humans Haplosclerida Pharmacology Pachychalina biology Molecular Structure Chemistry Alkaloid Organic Chemistry Biological activity biology.organism_classification Porifera Sponge Complementary and alternative medicine Molecular Medicine Female Cancer cell lines Drug Screening Assays Antitumor Brazil
Zdroj:	Journal of natural products. 70(4)
ISSN:	0163-3864
Popis:	Four bis-piperidine alkaloids, madangamine F (1), haliclonacyclamine F (2). and arenosclerins D (3) and E (4), have been isolated from the marine sponge Pachychalina alcaloidifera and have been identified by analysis of spectroscopic data. The alkaloids displayed cytotoxic activity against different cancer cell lines. These results support the hypothesis of a common biogenetic origin for the Haplosclerida bis-piperidine and bis-pyridine alkaloids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c30e590c4e823c32ab740e083a77c0d https://pubmed.ncbi.nlm.nih.gov/17346073 Zobrazit plný text záznamu