Insight into status of dental caries vaccination: A review
| Autor: | G V Rao, Sudheer B. Balla, Gayathri Cherukuri, Venkat Baghirath Pacha, Chandrasekhar Veeramachaneni |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
medicine.medical_specialty medicine.medical_treatment dental caries vaccine Review Article Passive immunity 01 natural sciences Streptococcus sobrinus World health Streptococcus mutans 03 medical and health sciences 0302 clinical medicine 010608 biotechnology Epidemiology Medicine General Dentistry biology business.industry 030206 dentistry biology.organism_classification Dental caries vaccine Vaccination stomatognathic diseases passive immunity Immunization Immunology business Active immunity |
| Zdroj: | Journal of Conservative Dentistry : JCD |
| ISSN: | 0972-0707 |
| DOI: | 10.4103/jcd.jcd_402_20 |
| Popis: | Despite advances in the 21st century, dental caries still remains to be one of the most common infectious diseases. Its prevalence was confirmed by the World Health Organization and affirms dental caries as a major health problem in all over the world. Even though the process of tooth decay is multifactorial, the oral bacteria, mutans streptococci, such as Streptococcus mutans and Streptococcus sobrinus, are considered to be causative agents of dental caries in human. Numerous studies carried out on animals and various categories of vaccines were developed such as whole cell vaccine, subunit vaccine, and synthetic peptides. Irrespective of success from active and passive immunization based on animal trials, it is the phenomenon of human heart reactivity that limited the applicability of these trials in humans. Continuous efforts are being made to overcome these limitations and for further success in human trials. With the advent of various antibodies against antigens of mutans streptococci, local passive immunization has become the safer approach in humans against the colonization of bacteria and caries induction. This review provided insight into epidemiology, active and passive immunization in both animal and human trials, as well as the prospects of caries vaccination. |
| Databáze: | OpenAIRE |
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