At what level of unilateral renal impairment does contralateral functional compensation occur?
| Autor: | Amnon Piepsz, Khalid Ismaili, Alain Prigent, Frank Collier, Hamphrey Ham, Michelle Hall |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Nephrology medicine.medical_specialty Adolescent Urology Renal function Kidney Internal medicine medicine Humans Child Inverse correlation Normal side business.industry Split function Adaptation Physiological Surgery medicine.anatomical_structure Child Preschool Contralateral kidney Pediatrics Perinatology and Child Health Kidney Diseases Both kidneys business Radioisotope Renography Glomerular Filtration Rate |
| Zdroj: | Pediatric Nephrology. 20:1593-1598 |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/s00467-005-1974-x |
| Popis: | Functional compensation occurs in a kidney when the function of the contralateral kidney is decreased or absent. What is, however, not documented is the level of unilateral renal impairment at which functional compensation occurs. Split function, as obtained from a radionuclide renogram, can only show the asymmetry between both kidneys. The aim of the present work was to evaluate at what level of unilateral impairment a functional compensation can be observed in the contralateral normal kidney. From a large database, 180 children over 2 years of age with unilateral pathology were retrospectively selected. All of them underwent a radionuclide study, combining a technetium-99m mercaptoacetyltriglycine (Tc-99m MAG3) renogram associated with a chromium-51 ethylenediaminetetraacetic acid (Cr-51 EDTA) overall clearance, allowing a precise estimation of single-kidney glomerular filtration rate (SKGFR). Below 30-35 ml/min/1.73 m2, there was a significant inverse correlation between SKGFR on the normal and the abnormal side. Above this level, no such correlation was observed, the mean SKGFR on the normal side remaining around 58 ml/min/1.73 m2, whatever the value of SKGFR on the abnormal side. In pediatric patients, hyperfunction occurs when SKGFR of the diseased kidney is below 30-35 ml/min/1.73 m2. |
| Databáze: | OpenAIRE |
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