Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology

Autor:	Punit Upadhyaya, Julia Kristensson, Johanna Lahdenranta, Elizabeth Repash, Jun Ma, Jessica Kublin, Gemma E. Mudd, Lia Luus, Phil Jeffrey, Kristen Hurov, Kevin McDonnell, Nicholas Keen
Rok vydání:	2022
Předmět:	Mice Tumor Necrosis Factor Receptor Superfamily Member 9 Neoplasms Drug Discovery Nectins Molecular Medicine Animals Cell Adhesion Molecules
Zdroj:	Journal of medicinal chemistry. 65(14)
ISSN:	1520-4804
Popis:	CD137 (4-1BB) is a co-stimulatory receptor on immune cells and Nectin-4 is a cell adhesion molecule that is overexpressed in multiple tumor types. Using a series of poly(ethylene glycol) (PEG)-based linkers, synthetic bicyclic peptides targeting CD137 were conjugated to
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c27610ba02170186a7dd0cfd287a4aa https://pubmed.ncbi.nlm.nih.gov/35819182 Zobrazit plný text záznamu