Impact of Prolonged Temporal Discrimination Threshold on Finger Movements of Parkinson's Disease
| Autor: | Myungsu Lee, Su-Hyang Kim, Mi Jeong Lee, Jayoung Lee, Jongsang Son, Chul Hyoung Lyoo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Kinematics Parkinson's disease Inertia Dopamine lcsh:Medicine Hands Audiology Biochemistry Basal Ganglia Correlation Catecholamines Discrimination Psychological 0302 clinical medicine Basal ganglia Medicine and Health Sciences Amines lcsh:Science Musculoskeletal System Aged 80 and over Movement Disorders Multidisciplinary Organic Compounds Physics Classical Mechanics Brain Neurodegenerative Diseases Parkinson Disease Neurochemistry Neurotransmitters Middle Aged Biomechanical Phenomena Arms Chemistry medicine.anatomical_structure Neurology Physical Sciences Tapping Female Anatomy Research Article Biogenic Amines medicine.medical_specialty Movement Sensory system Fingers Motion 03 medical and health sciences Finger movement medicine Humans Aged business.industry Limbs (Anatomy) Organic Chemistry lcsh:R Chemical Compounds Biology and Life Sciences Index finger medicine.disease Hormones stomatognathic diseases 030104 developmental biology Case-Control Studies Finger tapping lcsh:Q business Psychomotor Performance 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS ONE, Vol 11, Iss 11, p e0167034 (2016) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Introduction Sensory information is essential for the precise control of movement. Patients with Parkinson’s disease (PD) have higher-order sensory dysfunctions including prolonged temporal discrimination threshold (TDT). However, the impact of prolonged TDT on parkinsonian motor deficits is uncertain. Methods This study includes 33 PD patients and 24 healthy controls. TDT values were measured in the index finger. Using coin rotation task (CRT), dexterous finger movement was assessed. Using an inertial sensor, the speed, amplitude, and frequency of finger tapping were measured. The impact of prolonged index finger TDT on two different finger movements was analyzed using the general estimating equation. Results Compared to healthy controls, TDT was prolonged in the PD patients. There was no impact of TDT on mean values or decrement for amplitude and speed, as well as mean values, decrement and variability of tapping frequency. However, prolonged TDT had a significant impact on the variability in amplitude (B = 436.905 × 10−4, Wald χ2 = 9.140, p = 0.014) and speed (B = 425.655 × 10−4, Wald χ2 = 9.876, p = 0.014) of finger tapping. There was a marginal correlation between TDT and CRT. In addition, CRT correlated with variability in amplitude and speed of finger tapping. Conclusion In PD, cutaneous temporal discriminative sensory dysfunction appears to be related to increased variabilities in the speed and amplitude of fast repetitive finger movements and disturbed finger dexterity. |
| Databáze: | OpenAIRE |
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